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12/20/2025
Erectile dysfunction, also known as ED, is a widespread condition affecting millions of men globally. Erectile dysfunction does not just affect your ability to maintain an erection; it can hamper your self-esteem, harm your confidence, and might even undermine your relationship with your partner.
It is estimated that over 150 million men are affected by erectile dysfunction in the whole world, and this will only rise with the increasing population, if we don’t stop treating it like a Taboo. Thankfully, medications like Tadalafil and Vardenafil are easily available on the market.
Not sure which one to go for? Do not worry, we have got you covered. In this blog, we will talk about Tadalafil and Vardenafil's works and will do a quick comparison on a few crucial factors. This will help you to make an informed decision when choosing between the two.
Tadalafil and Vardenafil are both prescription medications that are used to treat erectile dysfunction. Both of them have a similar working mechanism and are classified as PDE5 inhibitors. When you start feeling sexually aroused, your brain sends out signals that lead to the release of nitric oxide through nerve endings and endothelial cells located in the penis.
After being released, nitric oxide activates the enzyme guanylate cyclase that escalates the production of a substance called cyclic guanosine monophosphate (cGMP) in smooth muscle cells. The extra cGMP relaxes and dilates the smooth muscle in your blood vessels, improving blood flow to the penis. PDE5 is an enzyme that catalyzes the breakdown of cGMP. As discussed above, cGMP helps vasodilate blood vessels, and improved blood flow helps sustain an erection.
Tadalafil and Vardenafil both bind to the active site of the PDE5 enzyme and inhibit its breakdown of cGMP. With PDE5 blocked, the levels of cGMP in your body elevate and allow better blood circulation, which helps in maintaining an erection for a longer period.
Before you buy erectile dysfunction tablets online, we want you to understand that none of these medications can cause an erection on their own. You need to be sexually aroused or have sexual stimulation. These medications can only assist by enhancing the response to arousal or in maintaining an erection; they cannot cause one. Having sexual stimulation or arousal is necessary for the medication to work.
When comparing drugs, it is important to discuss how quickly they start to work after consumption. It is a crucial question, as it helps the user to understand how soon they can expect to attain an erection after taking the medication. Also, there is no doubt that it can influence the decision of choosing between two medications. Both of these tablets are popular for their faster onset of action, but one of them is slightly faster than the other. Tadalafil is recommended to be taken at least 1 hour before engaging in sexual activities and takes around 45 minutes to 2 hours to reach its peak effectiveness.
Compared to Tadalafil, Vardenafil works faster and can start showing its effects within 30-60 minutes of consuming the tablet. In a few clinical trials, it was reported that some men achieved an erection within 15-30 minutes after taking Vardenafil. Due to its faster onset effects, it is advised to be taken 30 minutes before engaging in sexual activity. Before moving on to the next section, we want you to know that the onset time can vary person to person.
The duration of effect is one of the most prominent differences that can influence the verdict when choosing between Tadalafil and Vardenafil. Vardenafil is faster, but Tadalafil is the one that will give you a longer duration of effectiveness. While the effects of Vardenafil start to fade away after a few hours, Tadalafil has the tendency to remain active in our body for a duration of 36 hours. This medication is also known as the “Weekend Pill” because it breaks down very slowly in your body and stays in your body for a longer time. It has an average half-life of 17.5 hours, which means that it will take 17.5 hours for the drug to be reduced to half of its original concentration.
In contrast to Tadalafil, Vardenafil has a much shorter window of effectiveness. After you consume it, the effects typically last for a duration of 4-5 hours. This makes it a right fit for individuals who prefer planned sexual encounters.
Consuming a high-fat meal can delay the onset of action and absorption of Vardenafil. It is said to give fast results if taken on an empty stomach or after having a light meal. Tadalafil offers flexible options as it can be taken without food or after a meal. The type of meal consumed does not significantly affect the absorption rate of the drug.
Both Tadalafil and Vardenafil have their generic versions available. The original brand-name version of Vardenafil was discontinued by the manufacturer, and only its generic is now available. Generic Vardenafil would be cheaper than brand-name Tadalafil. But generic tadalafil is also cheaper than generic vardenafil, and its lower dosing frequency adds to its affordability. When you buy ED medication online, prices can vary among pharmacies. Buy erectile dysfunction tablets online from CompleteOnlinePharmacy.com for convenient delivery of your medical needs.
Vardenafil and Tadalafil have both emerged as effective ED medications and have helped millions of men regain their sexual confidence. Both of them have an assuring safety profile and have been approved to treat erectile dysfunction by the FDA. One of them has a faster onset of action, while the other one has a longer duration of effects. We want to tell you that the debate between the two drugs is endless; what’s important is that the drug should fulfill your needs and align with your personal goals.
Dealing with erectile dysfunction is a personal journey, and choosing the right drug should be based on personal needs. So the next time you are stuck in the dilemma of whether to buy Tadalafil Tablets or Vardenafil tablets. Figure out the purpose and make an informed decision. If you are still confused, it is best to discuss it with your healthcare provider.
Tadalafil and Vardenafil work by blocking the PDE5 enzyme and preventing it from breaking down the cGMP molecule. This helps in an increased level of cGMP in your body that relaxes the smooth muscles and widens the blood vessels in your penis. This results in a better flow of blood to the penis and helps in maintaining an erection upon sexual arousal.
Tadalafil lasts significantly longer than Vardenafil. Tadalafil (also known as the weekend pill) has an average half-life of 17 hours, and its effects can last up to 36 hours. Vardenafil, on the other hand, has a shorter duration of effects and typically works for about 4 to 6 hours.
Tadalafil and Vardenafil should be avoided by people who take nitrate medications for heart conditions or have a condition associated with high blood pressure. It is important to review the medication’s content before using it to prevent the risk of an allergic reaction. It is best to consult your doctor before taking this medication.
Tadalafil can be taken daily in low doses for conditions like erectile dysfunction (ED), benign prostatic hyperplasia (BPH), or pulmonary arterial hypertension (PAH). Vardenafil, however, is only approved for on-demand use and should not be taken daily.
No medication is free of side effects, and like other medications, these two have a few of their own. Vardenafil is said to have fewer side effects, such as headaches, flushing, or a stuffy nose, when compared with Tadalafil.
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