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05/16/2025
A "CANCER" terrifies most of us as it is the primary cause of death all around the globe. It's a word that floods our hearts with fear and pain. Almost every one of us has known someone, be it family or friend or even themselves, who has faced or is still facing this formidable disease. More than 10 million casualties are registered worldwide due to this horrific disease. Traditional therapies like chemotherapy, radiation, and surgery often have severe side effects and may not always be effective against advanced cancer cells. While research for a more effective cure is ongoing, two unexpected players- Ivermectin and Fenbendazole are enacting a crucial role in advancing cancer research and potentially advancing the ease of treating various types of cancer. A method referred to as drug repurposing is gaining a tremendous amount of attention as it creates more cost-effective ways of treatment. Recent drugs have seen a quicker transition to clinical trials and applications as well. Below, we will discuss these two drugs and what the recent studies say about the treatment against the deadly disease.
Have you ever wondered if a drug intended for one disease could be used unexpectedly to cure another? This is the potential of Drug repurposing. It is more cost-effective, faster, and safer than developing an entirely new drug. Scientists are investigating new uses for existing medications instead of creating new ones from the beginning. A drug named Thalidomide is a good example of this as doctors used to prescribe it for morning sickness, but later, it was used for the treatment of cancer and leprosy.
If you are confused about the term "repurposing", it simply means that; any existing medication initially developed to cure a disease that can now be used to treat cancer due to its anti-cancer properties can be called a "medication that is being repurposed for treating cancer." They can be used alone or with a combination of therapies available in the treatment of cancer. Ivermectin (prescribed to treat worm infection in humans) and Fenbendazole (widely used in veterinary medicine) are two powerful anti-parasitic drugs that have gained significant attention in both veterinary and human medicine, highlighting their ability to efficiently tackle a variety of parasitic infections.
You must have heard about this anti-parasitic drug (Ivermectin) at least once, as it is commonly used to treat infectious diseases like scabies, intestinal worms, and onchocerciasis. It is an FDA-approved, well-documented anti-parasite drug that combats parasitic infections. Additionally, recent laboratory evidence and animal studies suggest that Ivermectin may have anti-cancer properties.
It seems to obstruct the signaling pathways of cancer cells; it also affects cell division and interferes with mitochondrial function, and it may even enhance the immune system's ability to fight tumors. Ongoing studies indicate that Ivermectin has the potential to significantly inhibit tumor metastasis, a leading contributor to cancer-related mortality, either alone or in conjunction with chemotherapeutic drugs.
Moreover, the studies suggest that Ivermectin, as compared to chemotherapy, is more effective in inhibiting CSCs in breast cancer cells and shrinking tumor weight and volume in pancreatic cancer. Although it is not an approved drug for treating cancer, it is still being evaluated if it can be legally used as cancer medication.
Fenbendazole, widely used as a veterinary medicine to treat animal gastrointestinal parasites, came to the media's attention when a famous actor sparked a statement on a podcast discussion. He stated that the anti-parasitic drugs- Fenbendazole and Ivermectin played a crucial role in curing some of his friends who had stage 4 cancer.
The news spread like wildfire and caught the attention of the researchers studying pancreatic cancer. In their initial research stage, they found that these anti-parasitic drugs inhibit the growth and spread of cancer cells. Since this is an ongoing clinical trial, the investigation of the use of Fenbendazole in cancer treatment is still being processed despite promising results.
The available evidence is still initial, and more research is required to determine the appropriate dosage, safety, and success of Fenbendazole to treat different cancer types.Clinical trials and research explored the potential and traditional use of these anti-parasitic drugs in treating various human conditions like dengue fever and other viral infections.
On the other hand, the idea that these repurposed drugs can cure cancer seems to be intriguing; however, without solid clinical proof, it remains hypothetical. Stay curious but simultaneously cautious, and always consult your healthcare provider before trying any other therapy.
Introducing Anti-parasitic medications like Ivermectin and Fenbendazole, which were originally discovered to treat parasitic infections, into cancer treatment is going to be revolutionary in itself. Since these medications are already approved by the FDA for their safety and efficacy, they will enhance safety and reduce the side effects significantly.
It is also easily accessible to the general public, which ensures more patients receive the treatment they need. Additionally, this approach will potentially lower the overall cost of cancer treatment, making it a reasonable choice for more individuals. Although the idea of these repurposed drugs treating cancer feels compelling, the researchers still need solid evidence to determine if it is beneficial. Until then, it remains speculative.
Just by surfing through the internet, one can find that there are various cancer treatments available; however, the treatment that every individual needs depends upon several factors, such as the type and stage of the cancer. Your healthcare provider can calculate the risks and benefits of the type of treatment that is required for the patient.
Some of the treatments are mentioned below:
The most common treatment that we have always heard about Cancer is Chemotherapy. The word "Chemo" is used by most people to refer to drugs that can kill cancer cells and restrict them from growing and spreading to the other parts of the body. It may also shrink cancerous tumors. It's crucial to know that not all medicines or drugs treat cancer the same way.
Chemotherapy reaches almost all parts of our body and is usually used for treating cancers that arise from the bone marrow cells and lymph nodes, such as Leukaemia and Lymphoma.
Chemotherapy is a powerful option in treating cancer; however, it may also have common serious side effects, so you must always consult your doctor first before starting the treatment to check which kind of chemotherapy is right for you.
Surgery has been used for treating cancer for a long, long time. It also plays an important role in diagnosing cancer and assessing its spread in the body. In most cases, the only possible way to know if a person has cancer and the type of cancer is by taking a sample piece of the tissue and testing it. The sample piece is then kept under the microscope to detect the cancerous cells or perform lab tests on it. This entire procedure is called Biopsy. Sometimes, the only treatment you will need is surgery; however, in most cases, you will also have different cancer treatments along with the surgery.
Radiation therapy is the most common method of treatment that uses high-frequency rays to kill cancer cells. The location of the cancer, the type and the dosage of the radiation, your health, and several other factors are determined by your doctor before the therapy. According to a study, more than half of cancer patients undergo radiation therapy because sometimes it seems ideal as it only affects the specific parts of your body, unlike other treatments.
Immunotherapy uses a person's immune system to combat cancer. It can enhance or modify how the immune system functions, enabling it to identify and target cancer cells. The research of immunotherapy is rapidly increasing as it is used to treat many types of cancer and various conditions, such as autoimmune diseases, infectious diseases, and allergic reactions. Your doctor can determine if immunotherapy would benefit you or provide information about clinical trials investigating immunotherapy for your condition.
Targeted cancer therapies are drugs designed to control how cancer cells grow and spread by targeting Specific components of cancer cells, including proteins and genes. These types of therapies not only increase the efficacy of the treatment but also reduce the side effects without affecting normal or healthy cells of the body. As this form of treatment becomes increasingly essential, researchers conduct various studies to understand the specific changes in cancer cells better and develop more targeted drugs. Generally, patients receive targeted therapy in combination with other treatment methods.
Despite all the medical advancements and traditional therapies for cancer treatment, like chemotherapy, radiation, targeted therapy, surgery, and immunotherapy, cancer remains the second largest cause of death globally. While these treatments are effective, they have significant limitations and serious side effects.
Cancer is not just a single disease but a group of over 200 different types. Each type exhibits unique genetic mutations, distinct behaviors, and varying responses to cancer treatment. A universal cure for cancer may be impossible as each individual's cancer is different from another. Any treatment that works for one person may not work for another.
Cancer has the ability to develop resistance against the treatment over a period of time, complicating the efforts to control and manage the disease. In many cases, the treatment does not eradicate the cancer cells, and there are chances that the cancer will hit back stronger and in a more aggressive manner this time. No doubt, there is access to the latest therapies, but the question remains, "Is it easily accessible for those who cannot afford these high-cost therapies?"
While ongoing research is improving the treatment options, we still have to go a long way to make therapies easily accessible, more effective, and targeted, yet less harmful. For now, the existing treatment is life-saving but not the perfect solution in the fight against cancer.
One of the biggest challenges of the 21st century is curing cancer. New approaches to regulating the immune system in the battle against cancer are bringing us closer to a future where cancer may be considered a curable disease. Four key technologies—personalized vaccines, cell therapy, gene editing, and microbiome treatments—are set to transform how we treat cancer.
Many of the new technologies developed to combat cancer still need to prove their effectiveness in clinical trials. Even under ideal circumstances, it will take several years to become available to patients. However, we are moving toward a future where cancer treatment is personalized, increasing the chances of overcoming the disease like never before.
While we have made significant progress in combating cancer, and many treatments are currently available, it remains a leading cause of death worldwide, with nearly 10 million deaths recorded in 2020. The goal of our efforts is to ensure that patients diagnosed with cancer receive the right treatment at the right time and in the right dosage, allowing them to enjoy more time and a better quality of life. We also aim to shield them from cancer returning for the rest of their lives. The fight against cancer continues as we head into early preclinical studies, which suggest that Fenbendazole and Ivermectin, Antiparasitic drugs, may have the potential to treat cancer. However, further research and clinical trials are essential before conclusions about its effectiveness can be drawn.
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