Clomipramine is a tricyclic antidepressant. It affects chemicals in the brain that may be unbalanced.
Clomipramine is used to treat symptoms of obsessive-compulsive disorder such as recurrent thoughts or feelings and repetitive actions.
The health and medical information provided here is for general purposes only and is not a substitute for the expertise and judgment of your physician, or other health care professional. It should not be understood to indicate that the use of this medicine is safe, appropriate or effective for you. Always consult your health care professional before using this, or any other, drug.
Do not use clomipramine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.
Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, flu-like symptoms, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. This reaction may occur several weeks after you began using clomipramine.
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
Call your doctor at once if you have:
blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
rapid heart rate, tremors or shaking;
confusion, extreme fear, thoughts of hurting yourself;
painful or difficult urination; or
a seizure (convulsions).
Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.
Common side effects may include:
dry mouth, nausea, upset stomach, loss of appetite, constipation;
feeling anxious, restless, dizzy, drowsy, or tired;
sleep problems (insomnia);
appetite or weight changes;
memory problems, trouble concentrating;
increased sweating, numbness or tingling;
vision changes; or
decreased sex drive, impotence, or difficulty having an orgasm.
Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take clomipramine in larger or smaller amounts or for longer than recommended.
Take clomipramine with food to reduce stomach upset.
It may take up to 4 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve after 4 weeks of treatment.
Call your doctor if your symptoms do not improve, or if they get worse.
If you need surgery, tell the surgeon ahead of time that you are using clomipramine. You may need to stop using the medicine for a short time.
Do not stop using clomipramine suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using clomipramine.
Store at room temperature away from moisture and heat.
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